Skip navigation
Skip navigation

Universal molecular screening does not effectively detect Lynch syndrome in clinical practice

Brennan, Beatrice; Hemmings, Chris; Clark, Ian; Yip, Desmond; Fadia, Mitali; Taupin, Douglas

Description

Background: Lynch syndrome (LS) due to an inherited damaging mutation in mismatch repair (MMR) genes comprises 3% of all incident colorectal cancer (CRC). Molecular testing using immunohistochemistry (IHC) for MMR proteins is a recommended screening tool to identify LS in incident CRC. This study assessed outcomes of population-based routine molecular screening for diagnosis of LS in a regional center. Methods: We conducted a prospective, consecutive case series study of universal IHC testing...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/164879
Source: Therapeutic Advances in Gastroenterology
DOI: 10.1177/1756283X17690990
Access Rights: Open Access

Download

File Description SizeFormat Image
01_Brennan_Universal_molecular_screening_2017.pdf251.87 kBAdobe PDFThumbnail


This item is licensed under a Creative Commons License Creative Commons

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator