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Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens

Srinivas, Vivek; Lebrette, Hugo; Lundin, Daniel; Kutin, Yuri; Sahlin, Margareta; Lerche, Michael; Eirich, Jürgen; Branca, Rui M M; Cox, Nicholas; Sjöberg, Britt-Marie; Högbom, Martin

Description

Ribonucleotide reductase (RNR) catalyses the only known de novo pathway for the production of all four deoxyribonucleotides that are required for DNA synthesis1,2. It is essential for all organisms that use DNA as their genetic material and is a current drug target3,4. Since the discovery that iron is required for function in the aerobic, class I RNR found in all eukaryotes and many bacteria, a dinuclear metal site has been viewed as necessary to generate and stabilize the catalytic radical...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164807
Source: Nature
DOI: 10.1038/s41586-018-0653-6

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