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Questions concerning the role of amyloid-β in the definition, aetiology and diagnosis of Alzheimer's disease

Morris, Gary P; Clark, Ian; Vissel, Bryce


The dominant hypothesis of Alzheimer’s disease (AD) aetiology, the neuropathological guidelines for diagnosing AD and the majority of high-profile therapeutic efforts, in both research and in clinical practice, have been built around one possible causal factor, amyloid-β (Aβ). However, the causal link between Aβ and AD remains unproven. Here, in the context of a detailed assessment of historical and contemporary studies, we raise critical questions regarding the role of Aβ in the definition,...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Acta Neuropathologica
DOI: 10.1007/s00401-018-1918-8
Access Rights: Open Access


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