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NLRP3 regulates platelet aIIbβ3 outside-in signaling, hemostasis and arterial thrombosis

Qiao, Jianlin; Wu, Xiaoqing; Luo, Qi; Wei, Guangyu; Xu, Mengdi; Wu, Yulu; Liu, Yun; Li, Xiaoqian; Zi, Jie; Ju, Wen; Gardiner, Elizabeth


In addition to their hemostatic function, platelets play an important role in regulating the inflammatory response. The platelet NLRP3 inflammasome not only promotes interleukin-1β secretion, but was also found to be upregulated during platelet activation and thrombus formation in vitro. However, the role of NLRP3 in platelet function and thrombus formation in vivo remains unclear. In this study, we aimed to investigate the role of NLRP3 in platelet integrin aIIbβ3 signaling transduction. Using...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Haematologica
DOI: 10.3324/haematol.2018.191700
Access Rights: Open Access


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