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Mechanisms of resistance to the partner drugs of artemisinin in the malaria parasite

Martin, Rowena; Shafik, Sarah; Richards, Sashika


The deployment of artemisinin-based combination therapies (ACTs) has been, and continues to be, integral to reducing the number of malaria cases and deaths. However, their efficacy is being increasingly jeopardized by the emergence and spread of parasites that are resistant (or partially resistant) to the artemisinin derivatives and to their partner drugs, with the efficacy of the latter being especially crucial for treatment success. A detailed understanding of the genetic determinants of...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Current Opinion in Pharmacology
DOI: 10.1016/j.coph.2018.07.010


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