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Induction of genotype cross-reactive, hepatitis C virus-specific, cellmediated immunity in DNA-vaccinated mice

Wijesundara, Danushka K; Gummow, Gason; Li, Yanrui; Yu, Wenbo; Quah, Ben; Ranasinghe, Charani; Torresi, Joseph; Gowans, Eric J; Grubor-Bauk, Branka

Description

A universal hepatitis C virus (HCV) vaccine should elicit multiantigenic, multigenotypic responses, which are more likely to protect against challenge with the range of genotypes and subtypes circulating in the community. A vaccine cocktail and vaccines encoding consensus HCV sequences are attractive approaches to achieve this goal. Consequently, in a series of mouse vaccination studies, we compared the immunogenicity of a DNA vaccine encoding a consensus HCV nonstructural 5B (NS5B) protein to...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/164536
Source: Journal of Virology
DOI: 10.1128/JVI.02133-17

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