Induction of genotype cross-reactive, hepatitis C virus-specific, cellmediated immunity in DNA-vaccinated mice
A universal hepatitis C virus (HCV) vaccine should elicit multiantigenic, multigenotypic responses, which are more likely to protect against challenge with the range of genotypes and subtypes circulating in the community. A vaccine cocktail and vaccines encoding consensus HCV sequences are attractive approaches to achieve this goal. Consequently, in a series of mouse vaccination studies, we compared the immunogenicity of a DNA vaccine encoding a consensus HCV nonstructural 5B (NS5B) protein to...[Show more]
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|Source:||Journal of Virology|
|01_Wijesundara_Induction_of_genotype_2018.pdf||2.77 MB||Adobe PDF||Request a copy|
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