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IL-2 Enhances Gut Homing Potential of Human Naive Regulatory T Cells Early in Life

Hsu, Peter; Lai, C; Hu, M; Santner-Nanan, Brigitte; Dahlstrom, Jane; Lee, C. H.; Ajmal, Ajesha; Bullman, A; Arbuckle, Susan; Al Saedi, S; Gacis, L


Recent evidence suggests early environmental factors are important for gut immune tolerance. Although the role of regulatory T (Treg) cells for gut immune homeostasis is well established, the development and tissue homing characteristics of Treg cells in children have not been studied in detail. In this article, we studied the development and homing characteristics of human peripheral blood Treg cell subsets and potential mechanisms inducing homing molecule expression in healthy children. We...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1701533


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