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Development of Biomarkers for Inhibition of SLC6A19 (B0AT1)-A Potential Target to Treat Metabolic Disorders

Javed, Kiran; Cheng, Qi; Carroll, Adam; Truong, Thy; Broer, Stefan

Description

Recent studies have established that dietary protein restriction improves metabolic health and glucose homeostasis. SLC6A19 (B⁰AT1) is the major neutral amino acid transporter in the intestine and carries out the bulk of amino acid absorption from the diet. Mice lacking SLC6A19 show signs of protein restriction, have improved glucose tolerance, and are protected from diet-induced obesity. Pharmacological blockage of this transporter could be used to induce protein restriction and to treat...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/160750
Source: International Journal of Molecular Sciences
DOI: 10.3390/ijms19113597

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