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Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD)

Wong, Annette T Y; Mannix, Carly; Grantham, Jared J; Allman-Farinelli, Margaret; Badve, Sunil V; Boudville, Neil; Byth, Karen; Chan, Jessie; Coulshed, Susan; Edwards, Marie E; Jiang, Simon

Description

Introduction: Maintaining fluid intake sufficient to reduce arginine vasopressin (AVP) secretion has been hypothesised to slow kidney cyst growth in autosomal dominant polycystic kidney disease (ADPKD). However, evidence to support this as a clinical practice recommendation is of poor quality. The aim of the present study is to determine the long-term efficacy and safety of prescribed water intake to prevent the progression of height-adjusted total kidney volume (ht-TKV) in patients with...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/160671
Source: BMJ Open
DOI: 10.1136/bmjopen-2017-018794

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