Protonation state of inhibitors determines interaction sites within voltage-gated sodium channels
Voltage-gated sodium channels are essential for carrying electrical signals throughout the body, and mutations in these proteins are responsible for a variety of disorders, including epilepsy and pain syndromes. As such, they are the target of a number of drugs used for reducing pain or combatting arrhythmias and seizures. However, these drugs affect all sodium channel subtypes found in the body. Designing compounds to target select sodium channel subtypes will provide a new therapeutic pathway...[Show more]
|Collections||ANU Research Publications|
|Source:||PNAS - Proceedings of the National Academy of Sciences of the United States of America|
|Access Rights:||Open Access|
|01_Buyan_Protonation_state_of_2018.pdf||2.26 MB||Adobe PDF|
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