Lytic Promoters Express Protein during Herpes Simplex Virus Latency
Date
2016
Authors
Russell, Tiffany A
Tscharke, David C
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Abstract
Herpes simplex virus (HSV) has provided the prototype for viral latency with previously well-defined acute or lytic and latent phases. More recently, the deep quiescence of HSV latency has been questioned with evidence that lytic genes can be transcribed in this state. However, to date the only evidence that these transcripts might be translated has come from immunological studies that show activated T cells persist in the nervous system during latency. Here we use a highly sensitive Cre-marking model to show that lytic and latent phases are less clearly defined in two significant ways. First, around half of the HSV spread leading to latently infected sites occurred beyond the initial acute infection and second, we show direct evidence that lytic promoters can drive protein expression during latency.
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Keywords
animals, disease models, gene expression regulation, viral, herpes simplex, herpesvirus 1, human, mice, rna, viral, transcription, genetic, virus latency
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PLoS pathogens
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Journal article
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Open Access
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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits
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