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Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen – A cautionary tale in screening transgenic parasites

Tran, Phuong; Tate, Cameron; Ridgway, Melanie; Saliba, Kevin; Kirk, Kiaran; Maier, Alex


Ketotifen has recently been reported to inhibit the growth of both asexual and sexual malaria parasites. A parasite transporter, PfgABCG2, has been implicated in its mechanism of action. Human dihydrofolate reductase (hDHFR) is the most commonly used selectable marker to create transgenic Plasmodium falciparum cell lines. Growth assays using transgenic P. falciparum parasites with different selectable markers revealed that the presence of hDHFR rather than the absence of PfgABCG2 is responsible...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: International Journal for Parasitology: Drugs and Drug Resistance
DOI: 10.1016/j.ijpddr.2016.09.003
Access Rights: Open Access


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