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Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits

Durham, Mary F; Magwire, Michael M; Stone, Eric; Leips, Jeff

Description

Most organisms exhibit senescence; a decline in physiological function with age. In nature, rates of senescence vary extensively among individuals and this variation has a significant genetic component; however, we know little about the genes underlying senescence. Here we show the first evidence that individual alleles influence fecundity in an age-specific manner and so the genetic basis of natural variation in fecundity changes dramatically with age. We complete a genome-wide association to...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/153563
Source: Nature Communications
DOI: 10.1038/ncomms5338
Access Rights: Open Access

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