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The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome

Zhou, Yang; Zhu, Jianguo; Schermann, Geza; Ohle, Corina; Bendrin, Katja; Sugioka-Sugiyama, Rie; Sugiyama, Tomoyasu; Fischer, Tamas


Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome. However, the mechanism by which they are recognized and targeted to the exosome is not fully understood. Here we report that the MTREC complex, which has recently been shown to promote degradation of meiotic mRNAs and regulatory ncRNAs, is also the major nuclear exosome targeting complex for CUTs and unspliced pre-mRNAs in Schizosaccharomyces pombe. The MTREC complex specifically binds to CUTs, meiotic mRNAs and...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Nature Communications
DOI: 10.1038/ncomms8050
Access Rights: Open Access


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