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A bioinformatic strategy for the detection, classification and analysis of bacterial autotransporters

Celik, Nermin; Webb, Chaille T.; Leyton, Denisse; Holt, Kathryn E; Heinz, Eva; Gorrell, Rebecca; Kwok, Terry; Naderer, Thomas; Strugnell, R; Speed, Terence P; Teasdale, Rohan D.; Likic, Vladimir A.; Lithgow, Trevor

Description

Autotransporters are secreted proteins that are assembled into the outer membrane of bacterial cells. The passenger domains of autotransporters are crucial for bacterial pathogenesis, with some remaining attached to the bacterial surface while others are released by proteolysis. An enigma remains as to whether autotransporters should be considered a class of secretion system, or simply a class of substrate with peculiar requirements for their secretion. We sought to establish a sensitive search...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/153382
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0043245
Access Rights: Open Access

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