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Postgenomic Analyses reveal development of infectious Anaplasma phagocytophilum during transmission from ticks to mice

Mastronunzio, Juliana E; Kurscheid, Sebastian; Fikrig, Erol

Description

Obligate intracellular bacteria of the Rickettsiales order have evolved to colonize both arthropod and mammalian hosts, but few details are known about the bacterial adaptations that occur during transmission from blood-feeding arthropods to mammals. Here we apply proteomics and transcriptome sequencing to Anaplasma phagocytophilum, the agent of human granulocytic anaplasmosis, in Ixodes scapularis tick salivary glands, to detect proteins or genes expressed by the pathogen during transmission...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/152301
Source: Journal of Bacteriology
DOI: 10.1128/JB.06791-11
Access Rights: Open Access

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