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Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease

Mahawaththa, Mithun C; Pearce, Benjamin J G; Szabo, Monika; Graham, Bim; Klein, Christian D; Nitsche, Christoph; Otting, Gottfried

Description

The Zika virus presents a serious risk for global health. Crystal structures of different constructs of the Zika virus NS2B-NS3 protease (NS2B-NS3pro) have been determined with the aim to provide a basis for rational drug discovery. In these structures, the C-terminal β-hairpin of NS2B, NS2Bc, was observed to be either disordered (open conformation) or bound to NS3pro complementing the substrate binding site (closed conformation). Enzymatically active constructs of flaviviral NS2B-NS3 proteases...[Show more]

CollectionsANU Research Publications
Date published: 2017-06
Type: Journal article
URI: http://hdl.handle.net/1885/148492
Source: Antiviral research
DOI: 10.1016/j.antiviral.2017.03.011
Access Rights: Open Access

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