The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study
Ward, Stephanie Alison; Storey, Elsdon; Woods, Robyn L; Hamilton, Garun S; Kawasaki, Ryo; Janke, Andrew L; Naughton, Matthew T; O'Donoghue, Fergal; Wolfe, Rory; Wong, Tien Y; Reid, Christopher M; Abhayaratna, Walter; Stocks, Nigel; Trevaks, Ruth; Fitzgerald, Sharyn; Hodgson, Lauren A B; Robman, Liubov; Workman, Barbara; McNeil, John J
PURPOSE Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. DESIGN...[Show more]
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|Source:||Contemporary clinical trials|
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