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The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study

Ward, Stephanie Alison; Storey, Elsdon; Woods, Robyn L; Hamilton, Garun S; Kawasaki, Ryo; Janke, Andrew L; Naughton, Matthew T; O'Donoghue, Fergal; Wolfe, Rory; Wong, Tien Y; Reid, Christopher M; Abhayaratna, Walter; Stocks, Nigel; Trevaks, Ruth; Fitzgerald, Sharyn; Hodgson, Lauren A B; Robman, Liubov; Workman, Barbara; McNeil, John J

Description

PURPOSE Sleep disordered breathing (SDB) is highly prevalent in older adults. Increasing evidence links SDB to the risk of dementia, mediated via a number of pathways, some of which may be attenuated by low-dose aspirin. This study will evaluate, in a healthy older cohort, the prospective relationship between SDB and cognitive function, changes in retinal and cerebral microvasculature, and determine whether low-dose aspirin ameliorates the effects of SDB on these outcomes over 3years. DESIGN...[Show more]

CollectionsANU Research Publications
Date published: 2018-01
Type: Journal article
URI: http://hdl.handle.net/1885/139492
Source: Contemporary clinical trials
DOI: 10.1016/j.cct.2017.10.016

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