Skip navigation
Skip navigation

A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite

Tran, Phuong N; Brown, Simon H. J; Mitchell, Todd W; Matuschewski, Kai; McMillan, Paul J; Kirk, Kiaran; Dixon, Matthew W. A; Maier, Alexander G

Description

ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. The genome of the human malaria parasite, Plasmodium falciparum, encodes multiple members of this family, one of which, gABCG2, is transcribed predominantly in the gametocyte stage. Here we use gene deletion and tagging to investigate the expression, localization and function of gABCG2. The protein is found in a single dot-like lipid-rich structure within female, but...[Show more]

CollectionsANU Research Publications
Date published: 2014-09-08
Type: Journal article
URI: http://hdl.handle.net/1885/13815
Source: Nature Communications
DOI: 10.1038/ncomms5773

Download

File Description SizeFormat Image
ncomms5773.pdf1.32 MBAdobe PDFThumbnail
    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator