Mice lacking neutral amino acid transporter B⁰AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control
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Jiang, Yang; Rose, Adam J.; Sijmonsma, Tjeerd P.; Bröer, Angelika; Pfenninger, Anja; Herzig, Stephan; Schmoll, Dieter; Bröer, Stefan
Description
OBJECTIVE: Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion and supplementation of neutral amino acids have been discussed as strategies to improve insulin sensitivity. Here we characterise mice lacking the intestinal and renal neutral amino acid transporter B⁰AT1 (Slc6a19) as a model to study the consequences of selective depletion of neutral amino acids. METHODS: Metabolic tests,...[Show more]
Collections | ANU Research Publications |
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Date published: | 2015-02-17 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/13741 |
Source: | Molecular Metabolism |
DOI: | 10.1016/j.molmet.2015.02.003 |
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Jiang et al Mice Lacking Neutral Amino Acid Transporter 2015.pdf | 1.47 MB | Adobe PDF |
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