Skip navigation
Skip navigation

Mice lacking neutral amino acid transporter B⁰AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control

Jiang, Yang; Rose, Adam J.; Sijmonsma, Tjeerd P.; Bröer, Angelika; Pfenninger, Anja; Herzig, Stephan; Schmoll, Dieter; Bröer, Stefan


OBJECTIVE: Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion and supplementation of neutral amino acids have been discussed as strategies to improve insulin sensitivity. Here we characterise mice lacking the intestinal and renal neutral amino acid transporter B⁰AT1 (Slc6a19) as a model to study the consequences of selective depletion of neutral amino acids. METHODS: Metabolic tests,...[Show more]

CollectionsANU Research Publications
Date published: 2015-02-17
Type: Journal article
Source: Molecular Metabolism
DOI: 10.1016/j.molmet.2015.02.003


File Description SizeFormat Image
Jiang et al Mice Lacking Neutral Amino Acid Transporter 2015.pdf1.47 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator