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Mice lacking neutral amino acid transporter B⁰AT1 (Slc6a19) have elevated levels of FGF21 and GLP-1 and improved glycaemic control

Jiang, Yang; Rose, Adam J.; Sijmonsma, Tjeerd P.; Bröer, Angelika; Pfenninger, Anja; Herzig, Stephan; Schmoll, Dieter; Bröer, Stefan


OBJECTIVE: Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion and supplementation of neutral amino acids have been discussed as strategies to improve insulin sensitivity. Here we characterise mice lacking the intestinal and renal neutral amino acid transporter B⁰AT1 (Slc6a19) as a model to study the consequences of selective depletion of neutral amino acids. METHODS: Metabolic tests,...[Show more]

CollectionsANU Research Publications
Date published: 2015-02-17
Type: Journal article
Source: Molecular Metabolism
DOI: 10.1016/j.molmet.2015.02.003


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