Leptin treatment: facts and expectations
Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene. For these patients, leptin replacement therapy with metreleptin (a recombinant leptin analog) has improved or normalized most of their phenotypes, including normalization of endocrine axes, decrease in insulin...[Show more]
|Collections||ANU Research Publications|
|Source:||Metabolism: clinical and experimental|
|Paz-Filho et al Leptin Treatment 2015.pdf||4.38 MB||Adobe PDF|
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