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Leptin treatment: facts and expectations

Paz-Filho, Gilberto; Mastronardi, Claudio A; Licinio, Julio


Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene. For these patients, leptin replacement therapy with metreleptin (a recombinant leptin analog) has improved or normalized most of their phenotypes, including normalization of endocrine axes, decrease in insulin...[Show more]

CollectionsANU Research Publications
Date published: 2015-01
Type: Journal article
Source: Metabolism: clinical and experimental
DOI: 10.1016/j.metabol.2014.07.014


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