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Vaccinia virus F5 is required for normal plaque morphology in multiple cell lines but not replication in culture or virulence in mice

Dobson, Bianca; Procter, Dean J; Hollett, Natasha A; Flesch, Inge E. A; Newsome, Timothy P; Tscharke, David C


Vaccinia virus (VACV) gene F5L was recently identified as a determinant of plaque morphology that is truncated in Modified Vaccinia virus Ankara (MVA). Here we show that F5L also affects plaque morphology of the virulent VACV strain Western Reserve (WR) in some, but not all cell lines, and not via previously described mechanisms. Further, despite a reduction in plaque size for VACV WR lacking F5L there was no evidence of reduced virus replication or spread in vitro or in vivo. In vivo we...[Show more]

CollectionsANU Research Publications
Date published: 2014-04-05
Type: Journal article
Source: Virology
DOI: 10.1016/j.virol.2014.03.020


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