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Keyhole limpet haemocyanin – a model antigen for human immunotoxicological studies

Swaminathan, Ashwin; Dear, Keith; McMichael, Anthony J; Lucas, Robyn

Description

Immunization with a T-cell dependent antigen has been promoted as a reliable and sensitive tool for assessing the influence of putative immunotoxic exposures or agents on immune function. Keyhole limpet haemocyanin (KLH) is a very large, copper-containing protein molecule derived from the haemolymph of the inedible mollusc, Megathura crenulata. KLH is a highly immunogenic T-cell dependent antigen that is used increasingly in immunotoxicological studies, particularly in those involving animals....[Show more]

CollectionsANU Research Publications
Date published: 2014-11
Type: Journal article
URI: http://hdl.handle.net/1885/12233
Source: British Journal of Clinical Pharmacology 78.5 (2014): 1135–1142
DOI: 10.1111/bcp.12422

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