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Enterocyte-specific regulation of the apical nutrient transporter SLC6A19 (B0AT1) by transcriptional and epigenetic networks

Tümer, Emrah; Bröer, Angelika; Balkrishna, Sarojini; Jülich, Torsten; Bröer, Stefan

Description

Enterocytes are specialized to absorb nutrients from the lumen of the small intestine by expressing a select set of genes to maximize the uptake of nutrients. They develop from stem cells in the crypt and differentiate into mature enterocytes while moving along the crypt-villus axis. Using, as an example, the Slc6a19 gene, encoding the neutral amino acid transporter B0AT1, we studied regulation of the gene by transcription factors and epigenetic factors in the intestine. To investigate this...[Show more]

CollectionsANU Research Publications
Date published: 2013-10-11
Type: Journal article
URI: http://hdl.handle.net/1885/11964
Source: Journal of Biological Chemistry 288.47 (2013): 33813-23
DOI: 10.1074/jbc.M113.482760

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