Physico-chemical foundations underpinning microarray and next-generation sequencing experiments
Harrison, Andrew; Binder, Hans; Buhot, Arnaud; Burden, Conrad J; Carlon, Enrico; Gibas, Cynthia; Gamble, Lara J; Halperin, Avraham; Hooyberghs, Jef; Kreil, David P; Levicky, Rastislav; Noble, Peter A; Ott, Albrecht; Pettitt, B Montgomery; Tautz, Diethard; Pozhitkov, Alexander E.
Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next- generation sequencing (NGS). A physical understanding of the hybridization process helps to determine the accuracy of these technologies. The goal of a widespread research program is to develop reliable transformations between the raw signals reported by the technologies and individual molecular concentrations from an ensemble of nucleic acids....[Show more]
|Collections||ANU Research Publications|
|Source:||Nucleic Acids Research 41.5 (2013): 2779–2796|
|Harrison et al Physico-chemical foundations 2013.pdf||8.31 MB||Adobe PDF|
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