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Physico-chemical foundations underpinning microarray and next-generation sequencing experiments

Harrison, Andrew; Binder, Hans; Buhot, Arnaud; Burden, Conrad J; Carlon, Enrico; Gibas, Cynthia; Gamble, Lara J; Halperin, Avraham; Hooyberghs, Jef; Kreil, David P; Levicky, Rastislav; Noble, Peter A; Ott, Albrecht; Pettitt, B Montgomery; Tautz, Diethard; Pozhitkov, Alexander E.


Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next- generation sequencing (NGS). A physical understanding of the hybridization process helps to determine the accuracy of these technologies. The goal of a widespread research program is to develop reliable transformations between the raw signals reported by the technologies and individual molecular concentrations from an ensemble of nucleic acids....[Show more]

CollectionsANU Research Publications
Date published: 2013-01-09
Type: Journal article
Source: Nucleic Acids Research 41.5 (2013): 2779–2796
DOI: 10.1093/nar/gks1358


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