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Truncation of gene F5L partially masks rescue of vaccinia virus strain MVA growth on mammalian cells by restricting plaque size

Dobson, Bianca M; Tscharke, David C


Modified vaccinia virus Ankara (MVA) is a candidate vaccine vector that is severely attenuated due to mutations acquired during several hundred rounds of serial passage in vitro. A previous study used marker rescue to produce a set of MVA recombinants with improved replication on mammalian cells. Here, we extended the characterization of these rescued MVA strains and identified vaccinia virus (VACV) gene F5L as a determinant of plaque morphology but not replication in vitro. F5 joins a growing...[Show more]

CollectionsANU Research Publications
Date published: 2014-02
Type: Journal article
Source: Journal of General Virology 95(Pt 2) (2014):466-71
DOI: 10.1099/vir.0.058495-0


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