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Development of two distinct dendritic-like APCs in the context of splenic stroma

Periasamy, Pravin; Petvises, Sawang; O'Neill, Helen


Murine splenic stroma has been found to provide an in vitro niche for hematopoiesis of dendritic-like APC. Two distinct cell types have been characterized. The novel “L-DC” subset has cross-presenting capacity, leading to activation of CD8+ T cells, but not activating CD4+ T cells, which is consistent with their CD11cloCD11bhiMHC-II− phenotype. For L-DC, an equivalent tissue-specific APC has been found only in spleen. A second population of CD11chiCD11bloMHC-II+ cells resembling conventional...[Show more]

CollectionsANU Research Publications
Date published: 2013-03-20
Type: Journal article
DOI: 10.3389/fimmu.2013.00073


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