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Developing connections amongst key cytokines and dysregulated germinal centers in autoimmunity

Sweet, Rebecca A; Lee, Sau K; Vinuesa, Carola

Description

Systemic autoimmunity owing to overactivity of Tfh and dysregulated germinal centers has been described in mice and humans. Cytokines such as IL-21, IFN-γ, IL-6 and IL-17 are elevated in the plasma of mouse models of lupus, arthritis, and multiple sclerosis, and in subsets of patients with autoimmune disease. Monoclonal antibodies targeting these cytokines are entering clinical trials. While these cytokines exert pleiotropic effects on immune cells and organs, it is becoming clear that each and...[Show more]

CollectionsANU Research Publications
Date published: 2012-11-01
Type: Journal article
URI: http://hdl.handle.net/1885/11397
Source: Current Opinion in Immunology 24.6 (2012): 658–664
DOI: 10.1016/j.coi.2012.10.003

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