Circulating precursor CCR7loPD-1hi CXCR5+ CD4+ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure
Date
2013-10-17
Authors
He, Jing
Tsai, Louis M
Leong, Yew Ann
Hu, Xin
Ma, Cindy
Chevalier, Nina
Sun, Xiaolin
Vandenberg, Kirsten
Rockman, Steve
Ding, Yan
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier (Cell Press)
Abstract
Follicular B helper T (Tfh) cells support high affinity and long-term antibody responses. Here we found that within circulating CXCR5+ CD4+ T cells in humans and mice, the CCR7loPD-1hi subset has a partial Tfh effector phenotype, whereas CCR7hiPD-1lo cells have a resting phenotype. The circulating CCR7loPD-1hi subset was indicative of active Tfh differentiation in lymphoid organs and correlated with clinical indices in autoimmune diseases. Thus the CCR7loPD-1hi subset provides a biomarker to monitor protective antibody responses during infection or vaccination and pathogenic antibody responses in autoimmune diseases. Differentiation of both CCR7hiPD-1lo and CCR7loPD-1hi subsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5+ helper T cells are primarily generated before germinal centers. Upon antigen reencounter, CCR7loPD-1hi CXCR5+ precursors rapidly differentiate into mature Tfh cells to promote antibody responses. Therefore, circulating CCR7loPD-1hi CXCR5+ CD4+ T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory.
Description
Keywords
antibody, T cells, CXCR5+ CD4+ T cells, CCR7loPD-1hi CXCR5+ CD4+ T cells, immunological, early, memory
Citation
Collections
Source
Immunity 39.4 (2013): 770ā781
Type
Journal article