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Quantitative modeling of the molecular steps underlying shut-off of rhodopsin activity in rod phototransduction

Lamb, Trevor D.; Kraft, Timothy W.


PURPOSE: To examine the predictions of alternative models for the stochastic shut-off of activated rhodopsin (R*) and their implications for the interpretation of experimentally recorded single-photon responses (SPRs) in mammalian rods. THEORY: We analyze the transitions that an activated R* molecule undergoes as a result of successive phosphorylation steps and arrestin binding. We consider certain simplifying cases for the relative magnitudes of the reaction rate constants and derive the...[Show more]

CollectionsANU Research Publications
Date published: 2016-06-17
Type: Journal article
Source: Molecular Vision
Access Rights: Open Access


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