Quantitative modeling of the molecular steps underlying shut-off of rhodopsin activity in rod phototransduction
PURPOSE: To examine the predictions of alternative models for the stochastic shut-off of activated rhodopsin (R*) and their implications for the interpretation of experimentally recorded single-photon responses (SPRs) in mammalian rods. THEORY: We analyze the transitions that an activated R* molecule undergoes as a result of successive phosphorylation steps and arrestin binding. We consider certain simplifying cases for the relative magnitudes of the reaction rate constants and derive the...[Show more]
|Collections||ANU Research Publications|
|Lamb and Kraft Quantitative modeling of the 2016.pdf||909.37 kB||Adobe PDF|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.