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Extended Law of Corresponding States Applied to Solvent Isotope Effect on a Globular Protein

Bucciarelli, Saskia; Mahmoudi, Najet; Casal-Dujat, Lucía; Jéhannin, Marie; Jud, Corinne; Stradner, Anna


Investigating proteins with techniques such as NMR or neutron scattering frequently requires the partial or complete substitution of D₂O for H₂O as a solvent, often tacitly assuming that such a solvent substitution does not significantly alter the properties of the protein. Here, we report a systematic investigation of the solvent isotope effect on the phase diagram of the lens protein γB-crystallin in aqueous solution as a model system exhibiting liquid-liquid phase separation. We demonstrate...[Show more]

CollectionsANU Research Publications
Date published: 2016-05-05
Type: Journal article
Source: The journal of physical chemistry letters
DOI: 10.1021/acs.jpclett.6b00593
Access Rights: Open Access


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