Extended Law of Corresponding States Applied to Solvent Isotope Effect on a Globular Protein
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Bucciarelli, Saskia; Mahmoudi, Najet; Casal-Dujat, Lucía; Jéhannin, Marie; Jud, Corinne; Stradner, Anna
Description
Investigating proteins with techniques such as NMR or neutron scattering frequently requires the partial or complete substitution of D₂O for H₂O as a solvent, often tacitly assuming that such a solvent substitution does not significantly alter the properties of the protein. Here, we report a systematic investigation of the solvent isotope effect on the phase diagram of the lens protein γB-crystallin in aqueous solution as a model system exhibiting liquid-liquid phase separation. We demonstrate...[Show more]
Collections | ANU Research Publications |
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Date published: | 2016-05-05 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/111682 |
Source: | The journal of physical chemistry letters |
DOI: | 10.1021/acs.jpclett.6b00593 |
Access Rights: | Open Access |
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File | Description | Size | Format | Image |
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01_Bucciarelli_Extended_Law_2016.pdf | 1.22 MB | Adobe PDF |
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