Skip navigation
Skip navigation

Extended Law of Corresponding States Applied to Solvent Isotope Effect on a Globular Protein

Bucciarelli, Saskia; Mahmoudi, Najet; Casal-Dujat, Lucía; Jéhannin, Marie; Jud, Corinne; Stradner, Anna


Investigating proteins with techniques such as NMR or neutron scattering frequently requires the partial or complete substitution of D₂O for H₂O as a solvent, often tacitly assuming that such a solvent substitution does not significantly alter the properties of the protein. Here, we report a systematic investigation of the solvent isotope effect on the phase diagram of the lens protein γB-crystallin in aqueous solution as a model system exhibiting liquid-liquid phase separation. We demonstrate...[Show more]

CollectionsANU Research Publications
Date published: 2016-05-05
Type: Journal article
Source: The journal of physical chemistry letters
DOI: 10.1021/acs.jpclett.6b00593


File Description SizeFormat Image
01_Bucciarelli_Extended_Law_2016.pdf1.22 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator