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ROQUIN signalling pathways in innate and adaptive immunity

Athanasopoulos, Vicki; Ramiscal, Roybel R; Vinuesa, Carola G

Description

ROQUIN is an RNA-binding protein that plays important roles in both the innate and adaptive immune systems. ROQUIN binds to several key immune-relevant messenger RNA (mRNA) targets through its ROQ domain modulating their stability and influencing macrophage function and the peripheral homeostasis of T cells and B cells. More recently, the E3 ubiquitin ligase activity of the ROQUIN RING domain has been shown to be crucial for T-cell-dependent B-cell responses against infection. Defective ROQUIN...[Show more]

CollectionsANU Research Publications
Date published: 2016-04-23
Type: Journal article
URI: http://hdl.handle.net/1885/109188
Source: European journal of immunology
DOI: 10.1002/eji.201545956

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