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ROQUIN signalling pathways in innate and adaptive immunity

Athanasopoulos, Vicki; Ramiscal, Roybel R.; Vinuesa, Carola

Description

ROQUIN is an RNA-binding protein that plays important roles in both the innate and adaptive immune systems. ROQUIN binds to several key immune-relevant messenger RNA (mRNA) targets through its ROQ domain modulating their stability and influencing macrophage function and the peripheral homeostasis of T cells and B cells. More recently, the E3 ubiquitin ligase activity of the ROQUIN RING domain has been shown to be crucial for T-cell-dependent B-cell responses against infection. Defective ROQUIN...[Show more]

dc.contributor.authorAthanasopoulos, Vicki
dc.contributor.authorRamiscal, Roybel R.
dc.contributor.authorVinuesa, Carola
dc.date.accessioned2016-10-07T05:36:58Z
dc.date.available2016-10-07T05:36:58Z
dc.identifier.issn0014-2980
dc.identifier.urihttp://hdl.handle.net/1885/109188
dc.description.abstractROQUIN is an RNA-binding protein that plays important roles in both the innate and adaptive immune systems. ROQUIN binds to several key immune-relevant messenger RNA (mRNA) targets through its ROQ domain modulating their stability and influencing macrophage function and the peripheral homeostasis of T cells and B cells. More recently, the E3 ubiquitin ligase activity of the ROQUIN RING domain has been shown to be crucial for T-cell-dependent B-cell responses against infection. Defective ROQUIN activity can culminate in a range of diseases, such as systemic autoimmunity, immunodeficiency, and inflammatory bowel disorder. Here, we provide a current overview of the immunomodulatory role of ROQUIN defined by its ribonucleoprotein-like structure, its repertoire of mRNA targets shared by related RNA-binding enzymes, and its involvement in a range of intracellular signalling pathways central to shaping immune responses.
dc.description.sponsorshipC.G.V. is a recipient of an NHMRC ElizabethBlackburn Fellowship, and funding from NHMRC program andproject grants.
dc.publisherWiley-VCH Verlag
dc.rights© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.sourceEuropean journal of immunology
dc.subjectB cells
dc.subjectmacrophages
dc.subjectroquin
dc.subjectT cells
dc.subjectmRNA
dc.titleROQUIN signalling pathways in innate and adaptive immunity
dc.typeJournal article
local.identifier.citationvolume46
dc.date.issued2016-04-23
local.publisher.urlhttp://www.wiley-vch.de/en/
local.type.statusPublished Version
local.contributor.affiliationAthanasopoulos, V., John Curtin School of Medical Research, The Australian National University
local.contributor.affiliationRamiscal, R. R., John Curtin School of Medical Research, The Australian National University
local.contributor.affiliationVinuesa, C. G., John Curtin School of Medical Research, The Australian National University
local.description.embargo2037-12-31
local.identifier.essn1521-4141
local.bibliographicCitation.issue5
local.bibliographicCitation.startpage1082
local.bibliographicCitation.lastpage1090
local.identifier.doi10.1002/eji.201545956
CollectionsANU Research Publications

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