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APOE genotype and entorhinal cortex volume in non-demented community-dwelling adults in midlife and early old age

Bunce, David; Cherbuin, Nicolas; Gautam, Prapti; Sachdev, Perminder Singh; Easteal, Simon; Anstey, Kaarin


The apolipoprotein E (APOE) ε4 allele is a risk factor for the neuropathological decline accompanying Alzheimer's disease (AD) while, conversely, the ε2 allele offers protection. One of the brain structures exhibiting the earliest changes associated with the disease is the entorhinal cortex. We therefore investigated the volumes of the entorhinal cortex and other structures in the medial temporal lobe including the parahippocampal gyrus, temporal pole, and inferior, middle, and superior...[Show more]

CollectionsANU Research Publications
Date published: 2012-04-04
Type: Journal article
Source: Journal of Alzheimer's Disease 30.4 (2012): 935-942
DOI: 10.3233/JAD-2012-112126


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