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Lifetime cigarette smoking is associated with striatal volume measures

Das, Debjani; Cherbuin, Nicolas; Sachdev, Perminder Singh; Easteal, Simon; Anstey, Kaarin


Nicotine, the primary addictive component of tobacco, affects the mammalian brain. Smokers’ brains have smaller cortical grey matter volumes and/or lower densities compared with non-smokers’. Differences in subcortical structures like the striatum are however, less clear. A high concentration of nicotinic receptors makes the striatum a potential target for nicotine. In addition, striatal nuclei are essential components of the reward/reinforcement pathway involved in addiction. The aim of this...[Show more]

CollectionsANU Research Publications
Date published: 2011-03-11
Type: Journal article
Source: Addiction Biology 17.4 (2010): 817-825
DOI: 10.1111/j.1369-1600.2010.00301.x


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