Niches for extramedullary hematopoiesis in the spleen
The spleen is a major site for extramedullary hematopoiesis and adult mouse and human spleens retain low numbers of hematopoietic stem cells (HSC). Hematopoiesis is however dependent on stromal microenvironments that provide appropriate molecular signals. Recent evidence now suggests that a distinct stromal cell type exists in the spleen which can function as a niche for hematopoiesis. This review considers the role of the spleen in hematopoiesis, and the possibility that the spleen can be...[Show more]
|Collections||ANU Research Publications|
|Source:||Niche 1.1 (2012): 12-16|
|ONeill_NichesExtramedullary2012.pdf||110.23 kB||Adobe PDF|
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