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Niches for extramedullary hematopoiesis in the spleen

O'Neill, Helen


The spleen is a major site for extramedullary hematopoiesis and adult mouse and human spleens retain low numbers of hematopoietic stem cells (HSC). Hematopoiesis is however dependent on stromal microenvironments that provide appropriate molecular signals. Recent evidence now suggests that a distinct stromal cell type exists in the spleen which can function as a niche for hematopoiesis. This review considers the role of the spleen in hematopoiesis, and the possibility that the spleen can be...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Niche 1.1 (2012): 12-16
DOI: 10.5152/niche.2012.03


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