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Stroma-dependent development of two dendritic-like cell types with distinct antigen presenting capability

Periasamy, Pravin; O'Neill, Helen


Novel antigen presenting cells (APCs) have been described in the murine spleen. Cells have a distinct CD11c(lo)CD11b(hi)MHC-II(-)CD8α(-) phenotype as highly endocytic dendritic-like cells that cross-present antigen to CD8(+) T cells but fail to activate CD4(+) T cells. These cells are named "L-DCs" because they reflect dendritic cells (DCs) produced in long-term spleen cultures (LTC). Similar cells were produced when bone marrow progenitors were cocultured over the splenic stromal line 5G3....[Show more]

CollectionsANU Research Publications
Date published: 2012-11-22
Type: Journal article
Source: Experimental Hematology 41.3 (2013): 281-92
DOI: 10.1016/j.exphem.2012.11.003


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