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Technical advance: in vitro production of distinct dendritic-like antigen-presenting cells from self-renewing hematopoietic stem cells

Hinton, Rebecca A; O'Neill, Helen

Description

A novel CD11c(lo)CD11b(hi)MHC-II–CD8α– dendritic-like cell (L-DC) develops in cocultures of bone marrow over splenic stroma. L-DCs are distinct from other DC subsets and have potential importance in spleen for immunity to blood-borne antigens. As production is maintained in cultures for >12 months, L-DC development evidently depends on self-renewing progenitors. To improve this culture system, highly purified HSCs were sorted from bone marrow and used to establish cocultures. Nonadherent cells...[Show more]

CollectionsANU Research Publications
Date published: 2011-11-10
Type: Journal article
URI: http://hdl.handle.net/1885/10502
Source: Journal of Leukocyte Biology 91.2 (2012): 341-6
DOI: 10.1189/jlb.0611302
10.1189/jlb.0611302

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