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Immunodomination during peripheral vaccinia virus infection

Lin, Leon C. W.; Flesch, Inge E. A.; Tscharke, David C.


Immunodominance is a fundamental property of CD8+ T cell responses to viruses and vaccines. It had been observed that route of administration alters immunodominance after vaccinia virus (VACV) infection, but only a few epitopes were examined and no mechanism was provided. We re-visited this issue, examining a panel of 15 VACV epitopes and four routes, namely intradermal (i.d.), subcutaneous (s.c.), intraperitoneal (i.p.) and intravenous (i.v.) injection. We found that immunodominance is...[Show more]

CollectionsANU Research Publications
Date published: 2013-04-25
Type: Journal article
Source: PLoS Pathogens 9.4 (2013): e1003329
DOI: 10.1371/journal.ppat.1003329


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