Immunodomination during peripheral vaccinia virus infection
Immunodominance is a fundamental property of CD8+ T cell responses to viruses and vaccines. It had been observed that route of administration alters immunodominance after vaccinia virus (VACV) infection, but only a few epitopes were examined and no mechanism was provided. We re-visited this issue, examining a panel of 15 VACV epitopes and four routes, namely intradermal (i.d.), subcutaneous (s.c.), intraperitoneal (i.p.) and intravenous (i.v.) injection. We found that immunodominance is...[Show more]
|Collections||ANU Research Publications|
|Source:||PLoS Pathogens 9.4 (2013): e1003329|
|Lin_Immunodomination2013.pdf||1.09 MB||Adobe PDF|
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