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Evaluating the adequacy of molecular clock models using posterior predictive simulations

Duchene, David; Duchene, Sebastian; Holmes, Edward C.; Ho, Simon


Molecular clock models are commonly used to estimate evolutionary rates and timescales from nucleotide sequences. The goal of these models is to account for rate variation among lineages, such that they are assumed to be adequate descriptions of the processes that generated the data. A common approach for selecting a clock model for a data set of interest is to examine a set of candidates and to select the model that provides the best statistical fit. However, this can lead to unreliable...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Molecular Biology and Evolution
DOI: 10.1093/molbev/msv154


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