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Does eczema in infancy cause hay fever, asthma, or both in childhood? Insights from a novel regression model of sibling data

Hopper, J; Bui, Quang; Erbas, Bircan; Matheson, M; Gurrin, Lyle C; Burgess, John; Lowe, Adrian; Jenkins, Mark A; Abramson, M J; Walters, Haydn; Giles, Graham G; Dharmage, Shyamali

Description

Background: The atopic march hypothesis proposes that eczema precedes the development of asthma and allergic rhinitis. Objective: We sought to assess the evidence for a causal effect of infantile eczema on childhood hay fever, asthma, or both. Methods: We used parental reports on infantile eczema and childhood asthma and hay fever for 3778 pairs of 7-year-olds matched to their sibling closest in age within 2 years from the Tasmanian Longitudinal Health Study. We analyzed paired sibling data...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/103160
Source: Journal of Allergy and Clinical Immunology
DOI: 10.1016/j.jaci.2012.08.003

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