Familial focal epilepsy with variable foci mapped to chromosome 22q12: Expansion of the phenotypic spectrum
Date
2012
Authors
Klein, Karl
O'Brien, Terence J.
Praveen, Kavita
Heron, Sarah
Mulley, John C.
Foote, Simon
Berkovic, Sam F.
Scheffer, Ingrid
Journal Title
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Volume Title
Publisher
Blackwell Publishing Inc.
Abstract
Summary We aimed to refine the phenotypic spectrum and map the causative gene in two families with familial focal epilepsy with variable foci (FFEVF). A new five-generation Australian FFEVF family (A) underwent electroclinical phenotyping, and the original four-generation Australian FFEVF family (B) (Ann Neurol, 44, 1998, 890) was re-analyzed, including new affected individuals. Mapping studies examined segregation at the chromosome 22q12 FFEVF region. In family B, the original whole genome microsatellite data was reviewed. Five subjects in family A and 10 in family B had FFEVF with predominantly awake attacks and active EEG studies with a different phenotypic picture from other families. In family B, reanalysis excluded the tentative 2q locus reported. Both families mapped to chromosome 22q12. Our results confirm chromosome 22q12 as the solitary locus for FFEVF. Both families show a subtly different phenotype to other published families extending the clinical spectrum of FFEVF.
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Keywords
Keywords: adolescent; adult; article; Australia; child; chromosome 22q; clinical article; controlled study; electroencephalography; familial disease; female; focal epilepsy; gene locus; gene mapping; genetic variability; genome analysis; human; infant; male; phenot Chromosome 22q12; FFEVF; Focal epilepsy; FPEVF; Genetic epilepsy
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Source
Epilepsia
Type
Journal article
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2037-12-31
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