Integral-geometry characterization of photobiomodulation effects on retinal vessel morphology
Date
2014
Authors
Barbosa, Marconi
Natoli, Riccardo
Valter, Kriztina
Provis, Jan
Maddess, Ted
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Optical Society of America
Abstract
The morphological characterization of quasi-planar structures represented by gray-scale images is challenging when object identification is sub-optimal due to registration artifacts. We propose two alternative procedures that enhances object identification in the integral-geometry morphological image analysis (MIA) framework. The first variant streamlines the framework by introducing an active contours segmentation process whose time step is recycled as a multi-scale parameter. In the second variant, we used the refined object identification produced in the first variant to perform the standard MIA with exact dilation radius as multi-scale parameter. Using this enhanced MIA we quantify the extent of vaso-obliteration in oxygen-induced retinopathic vascular growth, the preventative effect (by photobiomodulation) of exposure during tissue development to near-infrared light (NIR, 670 nm), and the lack of adverse effects due to exposure to NIR light.
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Keywords
image analysis, medical and biological imaging, perception psychology
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Source
Biomedical Optics Express
Type
Journal article
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Open Access
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