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Pancreatic Islet Basement Membrane Loss and Remodeling After Mouse Islet Isolation and Transplantation: Impact for Allograft Rejection

Irving-Rodgers, H. F.; Choong, F. J.; Hummitzsch, K.; Parish, C. R.; Rodgers, R. J.; Simeonovic, C. J.


The isolation of islets by collagenase digestion can cause damage and impact the efficiency of islet engraftment and function. In this study, we assessed the basement membranes (BMs) of mouse pancreatic islets as a molecular biomarker for islet integrity, damage after isolation, and islet repair in vitro as well as in the absence or presence of an immune response after transplantation. Immunofluorescence staining of BM matrix proteins and the endothelial cell marker platelet endothelial cell...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Cell Transplantation
DOI: 10.3727/096368912X659880


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