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The NSAID sulindac is chemopreventive in the mouse distal colon but carcinogenic in the proximal colon

Mladenova, D.; Daniel, Joseph J; Dahlstrom, Jane; Bean, E.; Gupta, R.; Pickford, R.; Currey, N.; Musgrove, E. A.; Kohonen-Corish, M. R. J.


BACKGROUND AND AIMS The non-steroidal anti-inflammatory drug sulindac is an effective chemopreventive agent in sporadic colorectal cancer but its potential benefit in mismatch repair deficient cancers remains to be defined. We wanted to determine whether genetic defects that are relevant for colorectal cancer, such as Msh2 or p53 deficiency, would influence the efficiency of sulindac chemoprevention or increase the side effects. METHODS Msh2 or p53 deficient and wild-type mice received feed...[Show more]

CollectionsANU Research Publications
Date published: 2010-10-27
Type: Journal article
Source: Gut
DOI: 10.1136/gut.2010.208314


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