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Seminal Plasma Promotes Lesion Development in a Xenograft Model of Endometriosis

McGuane, Jonathan T; Watson, Katherine M; Zhang, Jamie; Johan, M Zahied; Wang, Zhao; Kuo, Gabriel; Sharkey, David J; Robertson, Sarah A; Hull, M Louise

Description

The factors that predispose one-tenth of reproductive-aged women to endometriosis are poorly understood. We determined that genetic deficiency in transforming growth factor β1 impairs endometriosis-like lesion growth in mice. Given that seminal plasma is an abundant source of transforming growth factor β, we evaluated the effect of exposure to seminal plasma on the growth of endometrial lesions. Human endometrial explants were exposed to seminal plasma or to control medium before transfer to...[Show more]

CollectionsANU Research Publications
Date published: 2015-05
Type: Journal article
URI: http://hdl.handle.net/1885/100219
Source: The American journal of pathology
DOI: 10.1016/j.ajpath.2015.01.010

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