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The evolution of the DLK1-DIO3 imprinted domain in mammals

Edwards, Carol A; Mungall, Andrew J; Matthews, Lucy; Ryder, Edward; Gray, Dionne J; Pask, Andrew J; Shaw, Geoffrey; Graves, Jennifer; Rogers, Jane; Dunham, Ian; Renfree, Marilyn B; Ferguson-Smith, Anne C


A comprehensive, domain-wide comparative analysis of genomic imprinting between mammals that imprint and those that do not can provide valuable information about how and why imprinting evolved. The imprinting status, DNA methylation, and genomic landscape of the Dlk1-Dio3 cluster were determined in eutherian, metatherian, and prototherian mammals including tammar wallaby and platypus. Imprinting across the whole domain evolved after the divergence of eutherian from marsupial mammals and in...[Show more]

CollectionsANU Research Publications
Date published: 2008-06-03
Type: Journal article
Source: PLoS Biology
DOI: 10.1371/journal.pbio.0060135


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