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The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals

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Edwards, Carol A; Rens, Willem; Clarke, Oliver; Mungall, Andrew J; Hore, Tim; Graves, Jennifer; Dunham, Ian; Ferguson-Smith, Anne C; Ferguson-Smith, Malcolm A

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BACKGROUND: The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome. RESULTS: Here we demonstrate that mammalian orthologues of imprinted genes are dispersed amongst autosomes in both monotreme and marsupial...[Show more]

dc.contributor.authorEdwards, Carol A
dc.contributor.authorRens, Willem
dc.contributor.authorClarke, Oliver
dc.contributor.authorMungall, Andrew J
dc.contributor.authorHore, Tim
dc.contributor.authorGraves, Jennifer
dc.contributor.authorDunham, Ian
dc.contributor.authorFerguson-Smith, Anne C
dc.contributor.authorFerguson-Smith, Malcolm A
dc.date.accessioned2009-05-06T04:44:09Z
dc.date.accessioned2010-12-20T06:06:08Z
dc.date.available2009-05-06T04:44:09Z
dc.date.available2010-12-20T06:06:08Z
dc.identifier.citationBMC Evolutionary Biology 7.157 (2007)
dc.identifier.issn1471-2148
dc.identifier.urihttp://hdl.handle.net/10440/227
dc.identifier.urihttp://digitalcollections.anu.edu.au/handle/10440/227
dc.description.abstractBACKGROUND: The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome. RESULTS: Here we demonstrate that mammalian orthologues of imprinted genes are dispersed amongst autosomes in both monotreme and marsupial karyotypes. CONCLUSION: These data, along with the similar distribution seen in birds, suggest that imprinted genes were not located on an ancestrally imprinted chromosome or associated with a sex chromosome. Our results suggest imprinting evolution was a stepwise, adaptive process, with each gene/cluster independently becoming imprinted as the need arose.
dc.format12 pages
dc.publisherBioMed Central
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.sourceBMC Evolutionary Biology
dc.source.urihttp://www.biomedcentral.com/content/pdf/1471-2148-7-157.pdf
dc.source.urihttp://www.biomedcentral.com/1471-2148/7/157
dc.subjectKeywords: animal; article; bacterial artificial chromosome; chromosome map; DNA probe; fluorescence in situ hybridization; genetics; genome imprinting; marsupial; molecular evolution; platypus; X chromosome inactivation; autosome; bird; evolution; gene cluster; gen
dc.titleThe evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals
dc.typeJournal article
local.identifier.citationvolume7
dcterms.dateAccepted2007-09-06
dc.date.issued2007-09-06
local.identifier.absfor060407
local.identifier.ariespublicationu9204316xPUB377
local.type.statusPublished Version
local.contributor.affiliationEdwards, Carol A, University of Cambridge
local.contributor.affiliationRens, Willem, University of Cambridge
local.contributor.affiliationMungall, Andrew J, Wellcome Trust Sanger Institute
local.contributor.affiliationHore, Tim, Research School of Biological Sciences, Comparative Genomics Research Group
local.contributor.affiliationGraves, Jennifer, Research School of Biological Sciences, Comparative Genomics Research Group
local.contributor.affiliationDunham, Ian, Wellcome Trust Sanger Institute
local.contributor.affiliationFerguson-Smith, Anne C, University of Cambridge
local.bibliographicCitation.startpage157 1
local.bibliographicCitation.lastpage24
local.identifier.doi10.1186/1471-2148-7-157
dc.date.updated2015-12-09T10:42:39Z
local.identifier.scopusID2-s2.0-35648932562
CollectionsANU Research Publications

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