A prospective evaluation of treatment with Selective Internal Radiation Therapy (SIR-spheres) in patients with unresectable liver metastases from colorectal cancer previously treated with 5-FU based chemotherapy
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Lim, Lionel; Gibbs, Peter; Yip, Desmond; Shapiro, Jeremy; Dowling, Robyn; Smith, D; Little, A; Bailey, W; Liechtenstein, Meir
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BACKGROUND: To prospectively evaluate the efficacy and safety of selective internal radiation (SIR) spheres in patients with inoperable liver metastases from colorectal cancer who have failed 5FU based chemotherapy. METHODS: Patients were prospectively enrolled at three Australian centres. All patients had previously received 5-FU based chemotherapy for metastatic colorectal cancer. Patients were ECOG 0–2 and had liver dominant or liver only disease. Concurrent 5-FU was given at...[Show more]
dc.contributor.author | Lim, Lionel | |
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dc.contributor.author | Gibbs, Peter | |
dc.contributor.author | Yip, Desmond | |
dc.contributor.author | Shapiro, Jeremy | |
dc.contributor.author | Dowling, Robyn | |
dc.contributor.author | Smith, D | |
dc.contributor.author | Little, A | |
dc.contributor.author | Bailey, W | |
dc.contributor.author | Liechtenstein, Meir | |
dc.date.accessioned | 2009-04-24T02:46:30Z | |
dc.date.accessioned | 2010-12-20T06:04:28Z | |
dc.date.available | 2009-04-24T02:46:30Z | |
dc.date.available | 2010-12-20T06:04:28Z | |
dc.identifier.citation | BMC Cancer 5.132 (2005) | |
dc.identifier.issn | 1471-2407 | |
dc.identifier.uri | http://hdl.handle.net/10440/145 | |
dc.identifier.uri | http://digitalcollections.anu.edu.au/handle/10440/145 | |
dc.description.abstract | BACKGROUND: To prospectively evaluate the efficacy and safety of selective internal radiation (SIR) spheres in patients with inoperable liver metastases from colorectal cancer who have failed 5FU based chemotherapy. METHODS: Patients were prospectively enrolled at three Australian centres. All patients had previously received 5-FU based chemotherapy for metastatic colorectal cancer. Patients were ECOG 0–2 and had liver dominant or liver only disease. Concurrent 5-FU was given at investigator discretion. RESULTS: Thirty patients were treated between January 2002 and March 2004. As of July 2004 the median follow-up is 18.3 months. Median patient age was 61.7 years (range 36 – 77). Twenty-nine patients are evaluable for toxicity and response. There were 10 partial responses (33%), with the median duration of response being 8.3 months (range 2–18) and median time to progression of 5.3 mths. Response rates were lower (21%) and progression free survival shorter (3.9 mths) in patients that had received all standard chemotherapy options (n = 14). No responses were seen in patients with a poor performance status (n = 3) or extrahepatic disease (n = 6). Overall treatment related toxicity was acceptable, however significant late toxicity included 4 cases of gastric ulceration. CONCLUSION: In patients with metastatic colorectal cancer that have previously received treatment with 5-FU based chemotherapy, treatment with SIR-spheres has demonstrated encouraging activity. Further studies are required to better define the subsets of patients most likely to respond. | |
dc.format | 6 pages | |
dc.publisher | BioMed Central | |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.source | BMC Cancer | |
dc.source.uri | http://www.biomedcentral.com/content/pdf/1471-2407-5-132.pdf | |
dc.source.uri | http://www.biomedcentral.com/1471-2407/5/132 | |
dc.subject | Keywords: fluorouracil; irinotecan; microsphere; oxaliplatin; proton pump inhibitor; yttrium 90; antineoplastic antimetabolite; fluorouracil; adult; aged; article; Australia; cancer adjuvant therapy; cancer growth; cancer survival; clinical article; clinical trial; | |
dc.title | A prospective evaluation of treatment with Selective Internal Radiation Therapy (SIR-spheres) in patients with unresectable liver metastases from colorectal cancer previously treated with 5-FU based chemotherapy | |
dc.type | Journal article | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 5 | |
dcterms.dateAccepted | 2005-10-15 | |
dc.date.issued | 2005-10-15 | |
local.identifier.absfor | 111299 | |
local.identifier.ariespublication | MigratedxPub11875 | |
local.type.status | Published Version | |
local.contributor.affiliation | Lim, Lionel, Royal Melbourne Hospital | |
local.contributor.affiliation | Gibbs, Peter, Royal Melbourne Hospital | |
local.contributor.affiliation | Yip, Desmond, ANU Medical School | |
local.contributor.affiliation | Shapiro, Jeremy, Cabrini Hospital Malvern | |
local.contributor.affiliation | Dowling, Robyn, Macquarie University | |
local.contributor.affiliation | Smith, D, Canberra Hospital | |
local.contributor.affiliation | Little, A, Cabrini Hospital Malvern | |
local.contributor.affiliation | Bailey, W, Cabrini Hospital Malvern | |
local.contributor.affiliation | Liechtenstein, Meir, Royal Melbourne Hospital | |
local.bibliographicCitation.issue | 132 | |
local.bibliographicCitation.startpage | doi:10.1186 | |
local.identifier.doi | 10.1186/1471-2407-5-132 | |
dc.date.updated | 2015-12-12T07:26:12Z | |
local.identifier.scopusID | 2-s2.0-27644528184 | |
Collections | ANU Research Publications |
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