Assembling branched and macrocyclic peptides on proteins
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Ullrich, Sven
Kumaresan, Santhanalaxmi
Rahman, Marina G.
Panda, Bishvanwesha
Morewood, Richard
Nitsche, Christoph
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Abstract
A two-step, biocompatible strategy enables site-specific generation of branched and macrocyclic peptide-protein conjugates. Solvent-exposed cysteines on proteins are modified by a small bifunctional reagent at near-physiological pH, followed by cyanopyridine-aminothiol click reactions to create branched or macrocyclic peptide architectures. This method offers design strategies for next-generation protein therapeutics.
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Chemical Communications
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